Overview At PNNL, our core capabilities are divided among major departments that we refer to as Directorates within the Lab, focused on a specific area of scientific research or other function, with its own leadership team and dedicated budget. Our Science & Technology directorates include National Security, Earth and Biological Sciences, Physical and Computational Sciences, and Energy and Environment. In addition, we have an Environmental Molecular Sciences Laboratory, a Department of Energy, Office of Science user facility housed on the PNNL campus. The Energy and Environment Directorate delivers science and technology solutions for the nation’s biggest energy and environmental challenges. Our more than 1,700 staff support the Department of Energy (DOE), delivering on key DOE mission areas including: modernizing our nation’s power grid to maintain a reliable, affordable, secure, and resilient electricity delivery infrastructure; research, development, validation, and effective utilization of renewable energy and efficiency technologies that improve the affordability, reliability, resiliency, and security of the American energy system; and resolving complex issues in nuclear science, energy, and environmental management. The Energy Processes and Materials Division, part of the Energy and Environment Directorate, creates and delivers real world solutions that support the Department of Energy’s goals for national energy security. We deliver new technologies that connect fundamental science to applications in areas such as energy storage, advanced materials manufacturing, applied catalysis, advanced separations, biomass conversions, carbon capture and utilization, and hydrogen production and storage. We employ a systems perspective that includes discovery, technology development, and scale-up as well as economic, regulatory, and market acceptance issues necessary for successful technology commercialization. Responsibilities We are seeking an outstanding computational researcher candidate to join our multi-disciplinary team focused on development of biological processes to produce renewable fuels and chemicals. In this position the candidate will have the opportunity to develop metabolic network models and whole-cell models for industrially relevant microorganisms and integrate multi-omics and bioprocess data using advanced computational biology and bioinformatics approaches. The candidate will work with the biology team to utilize cutting-edge capabilities such as synthetic biology, perturb-seq analysis, and causal machine learning to improve the biological processes within the program and other funding opportunities. The selected candidate is expected to: Conduct independent research and work on team assignments focusing on computational systems biology for fungi and yeast engineering, including metabolic flux analysis, whole-cell modeling, and Bayesian modeling approaches, lead manuscript development and maintain a strong overall publication record in the peer-reviewed scientific literature; Interact, communicate, and problem-solve with a diverse team of research staff across PNNL; Present research work at technical conferences, and Participate in the development of research proposals. Collaborates with researchers on the development and innovative application of advanced simulation, data analysis, visual analytics, or other computational techniques to research problems in the sciences, engineering, or other disciplines for which computational approaches are significant. May specialize in: Computational Chemistry: Uses computer simulation and develops new algorithms and implementations to investigate chemical systems. Computational Biology: Conducts research using bioinformatics theory and methods in areas such as biotechnology, computational biology, proteomics, computer information science, biology, and medical informatics. Qualifications Minimum Qualifications: BS/BA and 2 years of relevant experience -OR- MS/MA -OR- PhD Preferred Qualifications: PhD in Biological Engineering, Chemical Engineering, Computational Biology, Systems Biology, Biostatistics, Applied Mathematics, Computer Science, or Bioinformatics. Strong experience in metabolic network modeling and whole-cell modeling approaches. Expertise in flux balance analysis and 13C metabolic flux analysis. Proficiency in microbial perturb-seq experimental design and computational analysis. Experience with Bayesian metabolic control analysis and statistical modeling approaches. Advanced knowledge of multi-omics data integration and analysis (genomics, transcriptomics, proteomics, and metabolomics) Expertise in causal machine learning methods and their application to biological systems. Experience with kernel-based methods for statistical hypothesis testing and two-sample comparisons. Familiarity with process control, experimental design, and bioinformatics workflows. The ideal candidate possesses excellent written and oral communication skills, has demonstrated ability to collaborate effectively across interdisciplinary teams, has a track record of demonstrating initiative and problem-solving in complex biological systems, independent execution of computational research tasks, demonstrated ability to publish high-impact research in systems biology and metabolic engineering, and ability to rapidly learn and implement new computational methods and research techniques. Hazardous Working Conditions/Environment Not Applicable Testing Designated Position This is not a Testing Designated Position (TDP). About PNNL Pacific Northwest National Laboratory (PNNL) is a world-class research institution powered by a highly educated, diverse workforce committed to the values of Integrity, Creativity, Collaboration, Impact, and Courage. Every year, scores of dynamic, driven people come to PNNL to work with renowned researchers on meaningful science, innovations and outcomes for the U.S. Department of Energy and other sponsors; here is your chance to be one of them! At PNNL, you will find an exciting research environment and excellent benefits including health insurance, and flexible work schedules. PNNL is located in eastern Washington State—the dry side of Washington known for its stellar outdoor recreation and affordable cost of living. The Lab’s campus is only a 45-minute flight (or ~3 hour drive) from Seattle or Portland, and is serviced by the convenient PSC airport, connected to 8 major hubs. Commitment to Excellence and Equal Employment Opportunity Our laboratory is committed to fostering a work environment where all individuals are treated with fairness and respect while solving critical challenges in fundamental sciences, national security, and energy resiliency. We are an Equal Employment Opportunity employer. Pacific Northwest National Laboratory (PNNL) is an Equal Opportunity Employer. PNNL considers all applicants for employment without regard to race, religion, color, sex, national origin, age, disability, genetic information (including family medical history), protected veteran status, and any other status or characteristic protected by federal, state, and/or local laws. We are committed to providing reasonable accommodations for individuals with disabilities and disabled veterans in our job application procedures and in employment. If you need assistance or an accommodation due to a disability, contact us at [email protected]. Drug Free Workplace PNNL is committed to a drug-free workplace supported by Workplace Substance Abuse Program (WSAP) and complies with federal laws prohibiting the possession and use of illegal drugs. If you are offered employment at PNNL, you must pass a drug test prior to commencing employment. PNNL complies with federal law regarding illegal drug use. Under federal law, marijuana remains an illegal drug. If you test positive for any illegal controlled substance, including marijuana, your offer of employment will be withdrawn. Security, Credentialing, and Eligibility Requirements As a national laboratory, PNNL is responsible for adhering to the Homeland Security Presidential Directive 12 (HSPD-12) and Department of Energy (DOE) Order 473.1A, which require new employees to obtain and maintain a HSPD-12 Personal Identify Verification (PIV) Credential. To obtain this credential, new employees must successfully complete the applicable tier of federal background investigation post hire and receive a favorable federal adjudication. The tier of federal background investigation will be determined by job duties and national security or public trust responsibilities associated with the job. All tiers of investigation include a declaration of illegal drug activities, including use, supply, possession, or manufacture within the last 1 to 7 years (depending on the applicable tier of investigation). Illegal drug activities include marijuana and cannabis derivatives, which are still considered illegal under federal law, regardless of state laws. For foreign national candidates: If you have not resided in the U.S. for three consecutive years, you are not eligible for the PIV credential and instead will need to obtain a favorable Local Site Specific Only (LSSO) Federal risk determination to maintain employment. Once you meet the three-year residency requirement thereafter, you will be required to obtain a PIV credential to maintain employment. The tier of federal background investigation required to obtain the PIV credential will be determined by job duties at the time you become eligible for the PIV credential. Mandatory Requirements Please be aware that the Department of Energy (DOE) prohibits DOE employees and contractors from having any affiliation with the foreign government of a country DOE has identified as a “country of risk” without explicit approval by DOE and Battelle. If you are offered a position at PNNL and currently have any affiliation with the government of one of these countries, you will be required to disclose this information and recuse yourself of that affiliation or receive approval from DOE and Battelle prior to your first day of employment. Rockstar Rewards Employees and their families are offered medical insurance, dental insurance, vision insurance, health savings account, flexible spending accounts, basic life insurance, disability insurance*, employee assistance program, business travel insurance, tuition assistance, supplemental parental bonding leave**, surrogacy and adoption assistance, and fertility support. Employees are automatically enrolled in our company funded pension plan* and may enroll in our 401k savings plan. Employees may accrue up to 120 vacation hours per year and may receive ten paid holidays per year. * Research Associates excluded. **Once eligibility requirements are met. Click Here For Rockstar Rewards Notice to Applicants PNNL lists the full pay range for the position in the job posting. Starting pay is calculated from the minimum of the pay range and actual placement in the range is determined based on an individual’s relevant job-related skills, qualifications, and experience. This approach is applicable to all positions, with the exception of positions governed by collective bargaining agreements and certain limited-term positions which have specific pay rules. As part of our commitment to fair compensation practices, we do not ask for or consider current or past salaries in making compensation offers at hire. Instead, our compensation offers are determined by the specific requirements of the position, prevailing market trends, applicable collective bargaining agreements, pay equity for the position type, and individual qualifications and skills relevant to the performance of the position. Minimum Salary USD $97,900.00/Yr. Maximum Salary USD $146,900.00/Yr.