Site Name: Cambridge Binney Street Posted Date: Jan 28 2023 Patient-focused Research and Development (R&D) is the heart of our business. Our R&D department seeks to discover and develop new vaccines, to protect against diseases where vaccines are not yet available and to improve on those vaccines that already exist. Part of our R&D programme targets diseases particularly prevalent in the developing world, including the World Health Organisation’s three priority diseases - HIV/AIDS, tuberculosis and malaria. Research into candidate vaccines for other diseases of the developing world, such as dengue are at an earlier stage of development. When it comes to developing the vaccines of the future, we’re looking for real experts in their respective fields who are interested in working in the stimulating environment of an international healthcare company. You will be working with a novel, next generation approach to the development of vaccines and immunotherapies targeting infectious and other immune mediated diseases. This novel and highly efficient vaccine technology – called Multiple Antigen Presenting System (MAPS) – enables the high affinity binding of protective polysaccharides as well as proteins in a single vaccine, uniquely inducing a broad and protective B-cell and T-cell immune response. Within the MAPS Technology group, you will integrate with a multidisciplinary team in charge of purification, chemical modification and structural characterization of polysaccharides. You will be in close contact with experts in upstream, downstream and various analytical technologies. Your mission will be focused on the development and execution of downstream processes in different research and development contexts (early development, processability, process development, process understanding, troubleshooting, Life cycle…). The successful candidate will report to the manager of MAPS Technology, which is part of the Microbial Drug Substance organization in Technical R&D (TRD). Your Responsibilities: As Scientist/Associate Scientist, you will: Develop and optimize downstream polysaccharide purification processes using depth filtration, centrifugation, chromatography and tangential flow filtration (TFF). Design and perform chemical modification of polysaccharides and make MAPS. Perform stability studies of polysaccharides and MAPS. Characterize native and modified polysaccharides using SEC-MALS, GC/MS, LC/MS, NMR and other biochemical or biophysical assays. Write protocols for purification or conjugation process. Contribute to the transfer of developed processes to GMP facilities / CMOs to support Phase I/II trials. Document, summarize and present data. Additional duties and responsibilities as required. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: BS/MS in related fields such as Chemistry, Chemical Engineering, or Biochemistry, with 0-5 years of relevant experience. Title will be determined based on your educational background and working experience. Knowledge of synthetic chemistry and bioprocess techniques including chromatography and filtration. Hands on experience with HPLC and TFF systems. Independent, detail-oriented and organized. Demonstrated ability to work in a dynamic environment as a team player with a strong work ethic. As the group is a multidisciplinary organization, the willingness to develop beyond the initial expertise is a prerequisite to apply to this position. Good writing, communication and influencing skills. Interest for the laboratory work and lab management. Team spirit. Scientific curiosity. Preferred Qualifications: If you have the following characteristics, it would be a plus: Knowledge and experience with polysaccharide chemistry, NMR or mass spectrometry Experience in technology transfer and scale-up of drug substance processes Experience and training with DOE (Design of Experiments) and knowledge of QbD (Quality by Design) Understanding of operations and GMP manufacturing Experience in downstream processing, analytical methods, and data analysis Good organization skills (day-to-day operations and lab management) Imprinted with a desire for excellence Optimistic and open-minded Why GSK? At GSK we value diversity and treat all candidates equally. We aim to create an inclusive workplace where all employees feel engaged, supportive of one another and know their work makes an important contribution. We provide a supportive working environment and a range of development challenges and opportunities. We also offer competitive benefits and compensation packages designed to attract and to retain the very best. GSKBinneyStreet GSKAffinivax LI-GSK GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years. Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. 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