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Scientist, Cell Line Development, CHO Protein Vaccines


United States

United States || 107 Days Ago


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United States

Category :Engineering
Country :United States
publish date :2025-03-12
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Description


A career in Boston – main video (youtube.com) At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we’ve invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK’s long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life. GSK Vaccines is seeking a highly motivated scientist to join the Mammalian Expression Technologies Center of Excellence (MET CoE). Based in Cambridge, MA, this role is focused on the early development of production cell lines and genome engineering techniques to support platform innovation for recombinant protein-based vaccines. This position will play a significant role in shaping GSK’s vaccine pipeline to address unmet medical needs and accelerate global health initiatives. This is an exciting opportunity to integrate with a diverse group of talented industry experts, lead key cell line development activities, and further progress in your career. //Field-based worker - on-site// Main Responsibilities: Hands-on development of commercial CHO cell lines for recombinant protein-based vaccines by harnessing the understanding of cell x molecule x process Key contributor toward the design and implementation of new technologies and genome engineering strategies to support next-generation CHO platform innovation. Work effectively in a team environment to interpret project results and contribute to technical discussions by effectively communicating key updates to collaborators and team members. Maintain accurate and detailed laboratory notebooks and electronic records (e.g., SOPs, batch records, and reports) in compliance with company policies and current cGMP (related to raw material control strategies and cell line derivation) for accelerated CMC submissions. The candidate is also expected to spend time travelling (for 1 to 3 months) to Rockville, MD (Washington DC area) within the first year to support and ensure a smooth transition of the methods and the know-how to the new laboratories in Cambridge. Basic Qualifications: PhD, MS, or BS degree in Biochemistry, Cell Biology, Molecular Biology, Bioengineering or relevant fields with 1+ (PhD), 3+ (MS), or 5+(BS) years relevant experience within a pharmaceutical or biotech industry, respectively. One or more years of experience in developing early upstream manufacturing processes for engineered mammalian cell lines (CHO preferred). One or more years of experience with analytical assays such as PCR, qPCR, ddPCR, Octet, and Western blot. One or more years of experience using genome editing tools (such as CRISPR and transposases) to modify mammalian cell lines. Preferred Qualifications: Ability to embed advanced analytics (AI/ML) and data sciences to drive platform development and move to predictive in-silico design. Working understanding of US/EU regulatory requirements for CMC biologics development. Dedicated team player with a collaborative mindset to support cross-functional knowledge sharing. Proficiency with Microsoft Excel or statistical analysis software (JMP, Prism, etc.) for analyzing and presenting data. Ability to think critically, analytically, and demonstrate strong troubleshooting and problem-solving skills based on deductive reasoning. Ability to design and implement experiments with minimal technical supervision. Strong organizational and time management skills with the ability to prioritize and manage multiple tasks/project activities simultaneously. Li-GSK Vx-Cam Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/

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