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Scientific Leader, NMR


United States

United States || 436 Days Ago


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United States

Category :Engineering
Country :United States
publish date :2024-07-10
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Description


Site Name: USA - Pennsylvania - Upper Providence Posted Date: Jul 2 2024 An exciting opportunity for an enthusiastic analytical scientist to lead a team of NMR scientists within the Mass Spec and Characterization Team in Structure and Function Characterization, Analytical Development, MDS. The successful candidate will lead a team that utilizes state-of-the-art solution NMR and solid-state NMR instrumentation to generate critical data and provide key information enabling projects progression at all stages of pharmaceutical development, from Discovery through Development to marketing file, across small and large molecule portfolios. Reporting to the Team Director of Mass Spec and Characterization, the Team Leader will also be accountable for the development of NMR sciences for product development, whilst developing and promoting excellence in talent and culture within the team. Job Details: As a member of the Mass Spec and Characterization Leadership Team, provides leadership and direction to a team of NMR scientists to further the course of drug product development and enable key decisions. Leads the team’s efforts on product characterization for discovery chemistry, process development and manufacturing support, and contributions to regulatory submissions. Leads the team’s efforts in the evaluation of new capabilities and technologies. Acts as a scientific expert in discussions on science/project progression within GSK and contributes to regulatory dossiers and author/review expert reports. Continuously identify ways to simplify and improve ways of working. Creates an environment that stimulates, develops, and promotes the scientific and career development of others, including cross-training between modalities. Providing leadership through effective feedback, coaching, mentoring, and training to influence cultural change to deliver the strategic priorities. Identifies any technical or resource issues and propose/discuss solutions and strategies. Leading/supporting the interactions among different NMR teams within GSK to share scientific and project knowledge and harmonize ways of working in developing overall NMR strategies for process development and product characterization. Is accountable for safety and quality standards within the team. Basic Qualifications: A Ph.D. with ≥ 5 years or a Master’s degree with ≥ 10 years of experience in NMR focused on the structural elucidation of small and/or large molecules in support of Drug Product Development. Two or more years of experience managing a team of individual contributors or leading a scientific matrix team. Experience with product characterization requirements and practices during different stages of drug product development using NMR. Preferred Qualifications: Extensive knowledge of in-depth understanding of NMR spectroscopy and structure elucidation; demonstrated ability to apply 1D, 2D and heteronuclear NMR techniques specifically to the structural elucidation of small molecules (e.g., impurities/degradants/metabolites) and/or large molecules (e.g., oligonucleotides, proteins, monoclonal antibodies). Knowledge and/or experience in other spectroscopic and spectrometric techniques as it relates to structural elucidation. Sound understanding of pharmaceutical analytical strategies and product life cycle. Knowledge and experience in authoring relevant regulatory documents and interaction with global regulatory agencies Experience in leading or participating in multidisciplinary project teams and sub-teams, and excellent communication and interpersonal skills. Experience in analysis of protein and/or oligonucleotide therapeutics Experience in solid state NMR Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting For the Record site.

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