Scientist, Phenotypic Screening/Pathway/Target Deconvolution

Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us Leads Discovery and Optimization (LDO) is a dynamic organization that supports the entire continuum of drug discovery from lead identification to clinical candidate delivery at Bristol Myers Squibb. LDO leverages state of the art technologies, complemented by deep subject matter expertise and broad scientific knowledge, to deliver innovative and comprehensive preclinical in vitro datasets to support our drug discovery pipeline in disease areas such as oncology, immunology, fibrosis, cardiovascular diseases, neuroscience and cell therapy. We seek a highly motivated and innovative scientist to join a team that is currently building a Phenotypic Screening Center of Excellence for the purposes of accelerating drug discovery at Bristol Myers Squibb. The successful candidate will be responsible for developing, implementing, and integrating complex biological cellular models into high throughput small molecule compound screens. These models will include those derived from induced pluripotent stem cells and organoids, as well as a variety of human primary cells in a co-culture environment. This scientist will also participate in the deconvolution and linkage of attractive small molecule leads to their associated biological pathways and targets by the application of various functional genomics, transcriptomics, and proteomics approaches. The Phenotypic Screening Center of Excellence (CoE) will engage the entire drug discovery paradigm across all our therapeutic areas thereby providing a unique opportunity to make a significant impact across our portfolio. To be effective in this position the successful candidate will need to possess a broad, strong technical background in isolation and development of novel iPSC and primary 3-D cell culture models, combined with emerging functional genomics technologies in a high throughout setting, and strong communication skills. The successful candidate will have an intense desire to leverage and apply new approaches to the field of drug discovery and make a profound impact on the lives of patients. As a member of this team, a candidate is expected to collaborate effectively with academic and industry partners and be able to translate the knowledge gained from those collaborations into effective drug discovery solutions. This position is designed to enable Bristol Myers Squibb to maintain a leadership position in the application of novel and innovative genomic approaches to the drug discovery process. Job responsibilities Culturing and expansion of human iPSCs, human primary cells, and organoids for use in complex and disease-relevent phenotypic screens and related cellular assays Use of CRISPR Cas9/Cas12a/dCas9 technologies and the associated molecular biology/genome sciences to effectively implement 3-D cell culture environment for the purpose of developing novel disease-relevant models Work collaboratively with other CoE members to develop phenotypic screens, and design and develop hit screening deconvolution plans, and enable with cellular culturing expertise Apply deep knowledge of genome science to pathway/target deconvolution, using arrayed CRISPR screening methods Strong written & verbal communication skills for presenting data and ideas to multiple stakeholders across disciplines Basic Qualifications: Bachelor’s Degree with 5+ years of academic or industry experience Or Master’s Degree with 3+ years of academic or industry experience Or PhD and No years of experience Preferred Qualification: PhD in Molecular/Cellular Biology, Biochemistry, Bioengineering or related field, and 1-2 years of postdoc experience would be a plus Deep knowledge and proven expertise in the development of complex biological disease-related cellular models Demonstrated expertise in development of human iPSCs, 3-D primary cell culture and co-culture models is necessary Previous experience in expanding primary cells for high throughput screening purposes considered a plus Previous experience applying genome engineering methodologies in an arrayed format, and working knowledge of transcriptomics and sufficient bioinformatics expertise (e.g. with R and Python) to process genome-level data Publications resulting from MS- or PhD-level research experience would be advantageous Demonstrated excellence in written and oral communication Strong desire to succeed in cross-functional teams and collaborate in a highly matrixed environment If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture. COVID-19 Information To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S. BMS is dedicated to ensuring that people with disabilities can perform complex functions through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or in any part of the recruitment process, direct your inquiries to [email protected]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.