Scientist - Protein Chemistry

Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us Bristol Myers Squibb in San Diego is seeking a motivated individual with experience in protein purification and biochemical assays to join the Small Molecule Structural Biology and Proteomics West team in San Diego. The successful candidate will work with our team to purify proteins of interest, assess their stability and aggregation state, and test them in various biochemical and biophysical studies. The ideal candidate will be proficient in the purification of recombinant proteins for use in structural biology from E. coli , insect and mammalian cells, and have expertise using a range of protein chromatography and protein characterization techniques. BMS is a world leader in discovering novel therapeutics that harness the ubiquitin-proteasome system, and the successful candidate will have the opportunity to learn about this innovative drug discovery space, working with cross-functional project teams to enable novel drug discovery. Recent publications from our group include: https://www.nature.com/articles/s41589-018-0129-x https://www.nature.com/articles/nature18611 https://www.nature.com/articles/s41594-020-0405-9.pdf Job Responsibilities Manage and perform the design of constructs and expression of proteins of interest in E. coli. Experience in expressing proteins in insect and mammalian cells would be advantageous. Purify protein targets on various scales of interest for assays and structural studies. Characterize purified proteins by various biochemical and biophysical approaches. Basic Qualifications: Bachelor’s Degree and 5+ years of academic /industry experience Or Master’s degree and 3 years of academic / industry experience Or PhD and no experience required Preferred Qualifications: Ph.D. in biochemistry/structural biology with at least 3 years of pharmaceutical industrial experience in protein purification or structural biology. Substantial experience with designing protein constructs for structural biology Substantial experience with affinity (His, GST, MBP, and/or Avid tags), ion exchange and size exclusion chromatography techniques as applied to proteins. Experience with E. coli protein expression is required. Experience with insect and mammalian cell culture (e.g., expi293 cells) would be advantageous. Experience with common methods for protein characterization including SDS-PAGE, western blotting, and spectrophotometry is required. Experience with AKTA FPLCs is required, and experience in the production of highly pure proteins for use in structural biology is preferred. Previous experience characterizing protein samples by LC-MS would be advantageous. Experience with biophysical characterization, protein crystallization, or cryoEM techniques would be advantageous but are not required. Applicants must have strong organizational skills and the ability to work on multiple projects concurrently in a team-oriented environment. Strong written and oral communication skills are necessary to report on and deliver scientific presentations. Proficiency with Microsoft Excel, PowerPoint and Word is required. For California Sites - The starting compensation for this job is a range from $97,000 – 135,000, plus incentive cash and stock opportunities (based on eligibility). The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience. For more on benefits, please visit our BMS Careers site. Eligibility for specific benefits listed in our careers site may vary based on the job and location. If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture. COVID-19 Information To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S. BMS is dedicated to ensuring that people with disabilities can perform complex functions through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or in any part of the recruitment process, direct your inquiries to [email protected]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.