Senior Scientist / Investigator, Immune Cell Biology

Site Name: UK - Hertfordshire - Stevenage Posted Date: Nov 18 2022 353123 Senior Scientist / Investigator, Immune Cell Biology ***Please note that depending on experience, applicants may be considered for a position at either the G7 Investigator or G8 Senior Scientist level*** GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to support our mission to improve the quality of human life by enabling people to do more, feel better and live longer. We have an exciting opportunity available for a bright and innovative cell biologist to join GSK’s Immunology Research Unit in Stevenage. You will be working in a stimulating and fast-moving environment, where we put great emphasis on high quality science. You will join a multidisciplinary team focused on identifying future new medicines that target myeloid cells and cell-to-cell interactions. Our role is to identify novel genetically-associated targets for immune-mediated diseases through disease phenotyping, integration of genetic and genomic datasets (including via our collaboration with 23andMe), to validate these targets using disease- and mechanism-relevant in vitro cell and tissue-based assays, and to progress modulators of these targets through lead optimisation and into early clinical development. As a lab-based scientist, you will have the opportunity to contribute to our target validation, lead optimisation and disease expansion efforts. This could involve contributing to ongoing efforts to establish in vitro cellular and tissue-based assay systems that model immune cell interactions with other cell types, or applying such assay systems to the validation and progression of our growing portfolio of novel genetically-associated targets. The selected candidate will be expected to have excellent communication and organizational skills, present results at team and project meetings, and maintain accurate records. In this role you will As a cell biologist/immunologist, contribute to the validation, characterisation and progression of novel targets and therapeutics to treat diseases associated with dysregulated immune responses. Establish novel primary immune cell mono- and/or co-culture assay systems that mirror key aspects of disease for use in target validation and progression of drug candidates. Work collaboratively with Discovery teams to identify project needs and provide in vitro biology evidence to support project progression by agreed timelines. Maintain a high level of documentation for all experimental work to ensure data integrity expectations are met. Collaborate with key academic groups (or CROs) who can help further the programs or provide insight into the mechanism of action or therapeutic potential. Maintain an active knowledge of external developments in the field and adapting/initiating work plans (internally and externally) in response to emerging data. Engage and share expertise with wider Immunology Research Unit. Closing Date for Applications: November 30th, 2022 (COB) Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application. During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process. *LI-GSK Why you? Qualifications & Skills: We are looking for professionals with these required skills to achieve our goals: First or upper second-class honours degree in Immunology, chemistry, medicinal chemistry, chemical biology or related field Ph.D./D.Phil., or significant research experience, in the field of Immunology/biology/chemical biology /medicinal chemistry/molecular pharmacology or related field G8 level – Ph.D./D.Phil., or significant research experience and experience with in vitro cell based assays, cell cultures, flow cytometry, protein biochemistry G7 level – Significant and varied post-doc experience; this may include experience in a professional pharmaceutical/CRO environment Why GSK? Uniting science, technology and talent to get ahead of disease together GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years. Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. Find out more: Annual Report 2021 We’re combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatmento might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated. In 2021 we delivered four major product approvals: Cabenuva for HIV, Jemperli for endometrial cancer, Xevudy for COVID-19 and Apretude, our new long-acting medicine for HIV prevention. Find out more: Our approach to R&D GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years. Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. 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