Postdoctoral Fellow-MSH

Strength Through Diversity Ground breaking science. Advancing medicine. Healing made personal. Roles & Responsibilities: The Guccione Lab at the Icahn School of Medicine at Mount Sinai recently identified that inhibiting spliceosomal assembly through inhibition of arginine methylation provides an effective means of therapeutic splicing inhibition. Specifically, inhibiting either symmetric arginine methylation (mediated by the protein arginine methyltransferase 5 -PRMT5) or asymmetric dimethyl arginine methylation (mediated by type I PRMTs (PRMT1, 3, 4, and 6)) reduces splicing fidelity resulting in strong preferential killing of (i) splicing factor-mutant leukemias and (ii) MYC-overexpressing lymphomas over their wildtype counterparts. In addition the lab is investigating the role of members of the PRDM family of enzymes (e.g. PRDM9, PRDM10, PRDM15), in liver and colorectal cancer. The successful applicant will be part of a highly productive research team studying transcription and post-transcriptional regulation in the context of cancer, with direct translational applicability. Applicants should be highly motivated and driven to study cancer epigenetics and RNA biology. The successful candidate will be part of a thriving and diverse environment in the Department of Oncological Sciences within the Tisch Cancer Institute. The position offers competitive salary, subsidized postdoc-housing and exposure to a rich environment at Icahn School of Medicine at Mount Sinai and NYC. Requirements: • PhD in molecular biology or similar • Strong background in working with murine tumor models is a plus. • Background in cancer, RNA/chromatin biology and familiarity with recent advances in these fields and NGS technologies is a plus. • Excellent communication skills. Must be able to work as part of a small team and report data clearly. • Proactive and problem-solving attitude is important Strength Through Diversity The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by: Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers We work hard to acquire and retain the best people and to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong, and are able to professionally advance. We share the belief that all employees, regardless of job title or expertise, contribute to the patient experience and quality of patient care. Explore more about this opportunity and how you can help us write a new chapter in our history! Who We Are Over 42,000 employees strong, the mission of the Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve. Formed in September 2013, The Mount Sinai Health System combines the excellence of the Icahn School of Medicine at Mount Sinai with seven premier hospitals, including Mount Sinai Beth Israel, Mount Sinai Brooklyn, The Mount Sinai Hospital, Mount Sinai Queens, Mount Sinai West (formerly Mount Sinai Roosevelt), Mount Sinai St. Luke’s, and New York Eye and Ear Infirmary of Mount Sinai. The Mount Sinai Health System (MSHS) provides equal employment opportunity to all its employees and applicants for employment without unlawful discrimination on the basis of their actual or perceived race, creed, color, religion, national origin, sex, gender, gender expression, gender identity, age, disability, marital or parental status, sexual orientation, veteran, immigration, citizenship, or other protected status. EOE including Veterans and Disabled Compensation The Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $58,661.00 - $60,788.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.