Downstream Development Scientist

Nombre del sítio: UK - Hertfordshire - Stevenage Fecha de publicación: Aug 16 2022 We’re combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated. In 2021 we delivered four major product approvals: Cabenuva for HIV, Jemperli for endometrial cancer, Xevudy for COVID-19 and Apretude, our new long-acting medicine for HIV prevention. Find out more: Our approach to R&D Purification Development Scientist The Process De-risking team within the Biopharm Onestream group, R&D Stevenage, is looking for an enthusiastic and passionate scientist, to join its high performing team developing purification processes to support the progression of GSK’s innovative early stage Biopharm portfolio. This person will have the opportunity to work with state of the art purification hardware and robotic liquid handling systems, cutting edge analytics and execute the latest process development approaches. This pivotal lab-based role sits within GSK’s wider Biopharm Process Research (BPR) group, which straddles drug discovery and product development. Scientists can expect to deal with a range of different biomolecules, from monoclonal antibodies (mAbs) which render themselves amenable to platform purification, to more challenging modalities such as bispecific antibodies and recombinant proteins. In this role your responsibilities will include Developing robust and scalable purification processes and then transferring them to GSK’s large-scale manufacturing facilities, to supply Phase I clinical trials. The timely development and optimisation of robust downstream purification processes which can be scaled up to supply material for early-stage clinical trials (Phase I & II). Performing necessary work packages to characterise purification process performance and where necessary, highlight and discharge biomanufacturing risks. The production of reference batches of material to support analytical development and preclinical studies. Authoring detailed technical reports and process transfer documents to support tech transfer activities. The use of high-throughput automation in process development. Staying current with the latest Downstream purification technology improvements, and process development approaches, and leading continuous improvement efforts to maintain GSK’s technical competitiveness. Working with key stakeholders (e.g. Process and Analytical Development) to ensure alignment of processes and practices. Contributing to and potentially leading project and matrix teams as appropriate to deliver both the GSK portfolio as well as technology development objectives. Seeking all opportunities to develop and maintain a strong Intellectual Property position. Maintaining relationships with external professional, trade, and scientific organisations consistent with GSK business needs. Closing Date for Applications: Monday 29th August (COB) Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application. During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process. *LI-GSK Why you? Qualifications & Skills: We are looking for professionals with these required skills to achieve our goals: MSc or Bachelor’s degree in Biochemistry, Biotechnology, Biochemical Engineering or related discipline. Background in Protein Sciences and/or Biomanufacturing. Practical understanding of common downstream processing unit operations and Bioprocess development (with a focus at the early stage). Experience of working on complex research projects both as an individual and as part of a team. Preferred Qualifications & Skills: If you have the following characteristics, it would be a plus: PhD in related discipline and/or relevant industrial experience. Experience in running AKTA platforms such as AKTA Avant, AKTA Explorer and AKTA Pilot. Understanding of how the production of a protein can impact its structure and function and vice versa. Experience of working with a range of molecule formats such as bispecific, recombinant proteins, fc-fusions. Understanding of upstream processing operations and common challenges Understanding of process analytical technologies and/or upstream/cell culture concepts. Understanding of statistical design of experiments, and common data analysis and visualisation techniques. Strong ability to build professional relationships. Why GSK? Uniting science, technology and talent to get ahead of disease together GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years. Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. Find out more: Annual Report 2021 Como empresa impulsada por nuestros valores de enfoque al paciente, transparencia, respeto e integridad, sabemos que la inclusión y la diversidad son esenciales para que podamos tener éxito. Queremos que todos nuestros colegas prosperen en GSK, brindando sus experiencias únicas, asegurándonos de que se sientan bien y que sigan creciendo en sus carreras. Como candidato para un papel, queremos que usted se sienta de la misma manera. Creemos en una cultura de trabajo ágil para todos nuestros roles. Si la flexibilidad es importante para usted, lo alentamos a explorar con nuestro equipo de contratación cuáles son las oportunidades. No dude en ponerse en contacto con nosotros si desea analizar cualquier ajuste a nuestro proceso que pueda ayudarlo a demostrar sus fortalezas y capacidades. Puede llamarnos al 0808 234 4391 o enviar un correo electrónico [email protected]. A medida que lo solicite, le pediremos que comparta alguna información personal que sea voluntaria. Esto se utilizará para ayudarnos a comprender qué tan bien estamos haciendo frente a nuestras ambiciones de inclusión y diversidad. Realmente lo agradeceríamos si pudiera tomarse unos momentos para completarlo. Tenga la seguridad de que los gerentes de contratación no tienen acceso a esta información, no se utiliza en ninguna parte del proceso de selección y trataremos su información de forma confidencial y la utilizaremos de forma anónima.