Antibody Discovery Scientist

Site Name: UK - Hertfordshire - Stevenage Posted Date: Aug 9 2022 Are you a passionate scientist looking to be at the cutting edge of antibody discovery, working in a team instrumental in generating the monoclonal antibody therapy pipelines of the future? If so, this role is for you! We are currently seeking an enthusiastic and self-motivated antibody discovery scientist to join our Biopharm Discovery department. This role will be lab-centric and will involve the identification of antibodies using cutting edge yeast display and phage display techniques, and through molecular engineering the optimisation or affinity maturation into therapeutic grade leads. This role would allow you to gain experience and hone your skills as an antibody selections scientist and antibody engineer in a dynamic team of experts working at the early stages of developing world class future medicines. You would also gain exposure to other innovative technologies in use within the team such as B-cell sorting, screening, NGS, In silico-assisted design and ML. Although predominantly lab-based, you’ll have the opportunity to work within a hybrid home/ office-based model when possible. This role also involves important aspects of verbal and written communication and working within matrix teams across the department on therapeutic antibody programmes. Biopharm Discovery is a department within GSK’s Medicine Design group, part of a state-of-the-art and world-leading R&D Facility. The department is dedicated to the discovery of novel and effective biopharmaceutical medicines. We comprise a number of complementary functions focused on the progression of a portfolio of biopharmaceuticals from initial antibody discovery, expression and characterisation to molecular engineering and biological and physiochemical profiling. In this role you will Identify and optimise of antibodies using techniques for designing and engineering variants to optimise antibody quality and function within the laboratory. Use yeast display and phage display selection technologies, in addition to B-cell sorting and NGS capabilities. Be predominantly lab-based but will also need to utilise your strong verbal and written communication, good organisation and broader scientific knowledge to excel in the role. Work both individually and as part of a team. Utilise your interpersonal skills to work collaboratively to reach goals Why you? Qualifications & Skills: We are looking for professionals with these required skills to achieve our goals: PhD in a relevant field or equivalent level of experience in pharma, biotech or academia. Hands on experience of antibody discovery techniques including Phage display and/or Yeast display Lab-based molecular biology work experience: PCR, Sequence analysis, Cloning. Good scientific writing & verbal communication skills Good analytical and data interpretation skills with the ability to troubleshoot Ability to adapt quickly to new scientific areas Effective team working skills. Ability to multitask and work across multiple projects simultaneously. Preferred Qualifications & Skills: If you have the following characteristics, it would be a plus: Protein Engineering, such as in silico design, Directed Evolution or Library-based Engineering. Experience with Hybridoma and/or B cell screening techniques Structural biology experience, particularly with antibody structures and antigen complexes Familiarity with lab instrumentation, such as FACS cytometry within a (library) screening context Closing Date for Applications: Friday 26th August 2022 (COB) Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application. During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years. Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. Find out more: Annual Report 2021 R&D We’re combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated. In 2021 we delivered four major product approvals: Cabenuva for HIV, Jemperli for endometrial cancer, Xevudy for COVID-19 and Apretude, our new long-acting medicine for HIV prevention. Find out more: Our approach to R&D *LI-GSK As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way. As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only). We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are. Please don’t hesitate to contact us if you’d like to discuss any adjustments to our process which might help you demonstrate your strengths and capabilities. You can either call us on 0808 234 4391, or send an email [email protected] As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially. 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